Dehydro Nifedipine-13C,d3_product_DataBase

Bioactivity	Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine[1]. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Dehydro Nifedipine-13C,d3 相关抗体:
CAS	325484-33-1
Formula	C913CH10D3N5O4
Molar Mass	271.25
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Dipanjan Goswami, et al. Method Development Challenges and Regulatory Expectation in Nifedipine. International Journal of Pharmacokinetics, Volume 2, 2017 - Issue 1.

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