Daunorubicin citrate_product_DataBase

Bioactivity	Daunorubicin (Daunomycin) citrate is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin citrate inhibits DNA and RNA synthesis. Daunorubicin citrate is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin citrate is also an anthracycline antibiotic. Daunorubicin citrate can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor[1][2][4][5].
Invitro	Daunorubicin citrate (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells[2].Daunorubicin citrate (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells[3][4].Daunorubicin citrate (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells[4].Daunorubicin citrate (0.4 μM, 120 min) induces ROS generation in L3.6 cells[4].Daunorubicin citrate (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line)[6]. Cell Viability Assay[3][4] Cell Line:
Name	Daunorubicin citrate
CAS	1884557-85-0
Formula	C33H37NO17
Molar Mass	719.64
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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