| Bioactivity | Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. | ||||||||||||
| Invitro | Daun02 is a prodrug, which is converted by β-galactosidase to Daunorubicin, which has been shown to reduce calcium ion (Ca2+)-dependent action potentials in neuroblastoma cells[1]. Daunorubicin is a topoisomerase inhibitor[2]. Daun02 is a good substrate for β-galactosidase (β-gal). The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively[3]. | ||||||||||||
| Name | Daun02 | ||||||||||||
| CAS | 290304-24-4 | ||||||||||||
| Formula | C41H44N2O20 | ||||||||||||
| Molar Mass | 884.79 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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