| Bioactivity | Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5]. | ||||||||||||
| Invitro | 氨苯砜 (0.06 mM; 30 min) 抑制 N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) 和生理激动剂 C5a (100 nM) 触发的细胞内外超氧化物 (O2-) 和胰蛋白酶 E 的释放，而不是对 Phorbol 12-myristate 13-acetate (HY-18739) (100 nM) 没有作用[5]。 | ||||||||||||
| Name | Dapsone-d8 | ||||||||||||
| CAS | 557794-38-4 | ||||||||||||
| Formula | C12H4D8N2O2S | ||||||||||||
| Molar Mass | 256.35 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Dapsone-d8
CAS: 557794-38-4 F: C12H4D8N2O2S W: 256.35
Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic
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