| Bioactivity | Danuglipron (PF-06882961) tromethamine is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron tromethamine has the potential for type 2 diabetes research[1][2]. |
| Invitro | Danuglipron (PF-06882961) tromethamine 在 cAMP 和 βArr 通路上均显示出激动剂活性。Danuglipron 是 CS cAMP 测定中的完全激动剂（EC50 为 13 nM）。Danuglipron tromethamine 是募集 βArr2 的部分激动剂（EC50 为 490 nM）[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Danuglipron tromethamine 相关抗体: |
| In Vivo | Danuglipron（PF-06882961；10 mg/kg；口服；单剂量）tromethamine 可降低 hGLP-1R 小鼠模型腹膜内葡萄糖耐量试验 (IPGTT) 后的血糖水平[2]。Danuglipron 在雄性 Wistar 大鼠和雄性食蟹猴体内的药代动力学参数[1]。1.19 Species |
| CAS | 2230198-03-3 |
| Formula | C35H41FN6O7 |
| Molar Mass | 676.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. David A Griffithm, et al. A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. J Med Chem. 2022 Jun 23;65(12):8208-8226. [2]. W. GUO, et al. Preclinical pharmacology of low molecular weight GLP-1 receptor agonist XW014. |
Danuglipron tromethamine
CAS: 2230198-03-3 F: C35H41FN6O7 W: 676.73
Danuglipron (PF-06882961) tromethamine is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipro
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