| Bioactivity | Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2]. | ||||||||||||
| Invitro | Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases)[1]. | ||||||||||||
| Name | Daminozide | ||||||||||||
| CAS | 1596-84-5 | ||||||||||||
| Formula | C6H12N2O3 | ||||||||||||
| Molar Mass | 160.17 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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