| Bioactivity | Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease[1][2][3]. |
| Invitro | Dalazatide (ShK-186) (0-1000 pM) 以剂量依赖的方式阻断卵巢特异性 GFP+ 效应记忆 T (Tem) 细胞中的 Kv1.3 电流，Kd 为 65 ± 5 pM[3]。Dalazatide (0-100 nM; 3 days) 以剂量依赖的方式抑制 CCR7− T 细胞增殖[3]。Dalazatide (100 nM; 30 min) 通过抑制钙信号通路固定炎症部位的效应记忆 T (Tem) 细胞，从而阻止 β1 整合素激活[3]。 Cell Proliferation Assay[3] Cell Line: |
| Name | Dalazatide |
| CAS | 1081110-69-1 |
| Formula | C184H296N57O55PS7 |
| Molar Mass | 4442.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Dalazatide
CAS: 1081110-69-1 F: C184H296N57O55PS7 W: 4442.08
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of aut
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