| Bioactivity | Dafsolimab (SPV-T3a) is an IgG2a murine monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD)[1]. |
| Invitro | SPV-T3a-dgA (1.8 μg/mL) 在没有 PHA 激活的情况下，活细胞减少 2.0-2.7 倍。PHA激活48小时后，SPV-T3a-DGA 的最大杀伤力增加约 3 倍。 |
| Name | Dafsolimab |
| CAS | 2367001-71-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. van Oosterhout YV, et al. A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease. Blood. 2000 Jun 15;95(12):3693-701. |