| Bioactivity | DXR-IN-2 is a 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) inhibitor and an antimalarial agent (IC50: 0.1062 μM for Plasmodium falciparum DXR and 0.369 μM for Plasmodium falciparum). DXR-IN-2 inhibits Plasmodium falciparum growth by suppressing the methyl erythritol phosphate (MEP) pathway via DXR[1]. |
| Invitro | DXR-IN-2 (Compound 11a) (0.10-100 μg/mL, 24 h) 对 HepG2 的细胞毒性可以忽略不计，IC50 大于 50 μM[1]。DXR-IN-2 (0.5 ng/mL-100 μg/mL, 3 天) 通过 DXR 抑制 MEP 通路从而抑制恶性疟原虫 3D7 生长[1]。DXR-IN-2 (1 μM) 在小鼠肝微粒体中稳定存在超过 1 h[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DXR-IN-2 相关抗体: |
| CAS | 2260608-07-7 |
| Formula | C10H12NO5P |
| Molar Mass | 257.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang X, et al. MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase. ACS Infect Dis. 2023, 9(7):1387-1395. |