| Bioactivity | DXR-IN-1 (Compound 13E) is an inhibitor of 1-deoxy-D-ketose 5-phosphate reductoisomerase (DXR). DXR-IN-1 is highly selective for P. falciparum DXR (IC50=0.030 μM). DXR-IN-1 inhibits the growth of P. falciparum by binding to the active site of DXR and blocking its catalytic activity[1]. |
| Invitro | DXR-IN-1 对 DXR 的抑制效果分别为 IC50=0.035 μM (E. col)， 3.0 μM (M. tuberculosis)[1]。DXR-IN-1 抗疟原虫活性 分别为 IC50=0.55 μM (Pf3D7)， 0.94 μM (PfDd2)[1]。DXR-IN-1 的细胞毒性为 IC50=>1000 μM (HepG-2)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DXR-IN-1 相关抗体: |
| Formula | C19H24NO5P |
| Molar Mass | 377.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abdullaziz MA et al. Reverse N-Substituted Hydroxamic Acid Derivatives of Fosmidomycin Target a Previously Unknown Subpocket of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR). ACS Infect Dis. 2024 May 10;10(5):1739-1752. |