| Bioactivity | DV-B-120 is a competitive inhibitor for dengue virus (DENV) with IC50s of 5.35, 7.39, 10.49 and 8.58 μM, for DENV-1, DENV-2, DENV-3 and DENV-4, respectively, by inhibiting NS2B-NS3 protease. DV-B-120 exhibits antiviral activity through inhibition of DENV replication[1]. |
| Target | IC50: 5.35 μM (DENV-1), 7.39 μM (DENV-2), 10.49 μM (DENV-3), 8.58 μM (DENV-4) |
| In Vivo | DV-B-120 (1-10 mg/kg，b.i.d，脑室内注射，5 天) 通过激活干扰素 (IFN) 和抗病毒的 IFN 刺激基因 (ISG)，抑制感染 DENV-2 的 ICR 乳鼠的死亡，以及相关疾病症状[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C23H18N2O5S2 |
| Molar Mass | 466.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang Y-J, et al., Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection. J Virol. 2024 Apr 16;98(4):e0125823. |