| Bioactivity | DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects[1][2]. |
| In Vivo | DU125530 (3 mg/kg; s.c.) 在野生型小鼠中的降低 8-OH-DPAT (HY-112061) 诱导的 5-HT 释放的减少[1]。 Animal Model: |
| Name | DU125530 |
| CAS | 161611-99-0 |
| Formula | C23H26ClN3O5S |
| Molar Mass | 491.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mos J, et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1;325(2-3):145-53. [2]. Scorza MC, et al. Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov;167(5):1021-34. |
DU125530
CAS: 161611-99-0 F: C23H26ClN3O5S W: 491.99
DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-H
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