| Bioactivity | DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3]. |
| Invitro | DU-14 (0.001-10 μM，18 h) 抑制 MDA-MB-23l 细胞中的雌酮硫酸酯酶活性，IC50 为 350 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DU-14 相关抗体: |
| In Vivo | DU-14 (30 mg/kg，腹腔注射，一次) 抑制脑和肝组织中的类固醇硫酸酯酶活性，并可增强 DHEAS 对scopolamine 诱导的失忆大鼠的记忆增强特性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 186303-55-9 |
| Formula | C22H38N2O4S |
| Molar Mass | 426.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Selcer KW, et al. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines. Cancer Res. 1997 Feb 15;57(4):702-7. [2]. Li PK, et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine. Life Sci. 1997;60(3):PL45-51. [3]. Yue XH, et al. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Horm Behav. 2016 Jul;83:83-92. |