| Bioactivity | DT-6 is an effective TGF-β1 inhibitor. DT-6 inhibits M2 macrophage induced epithelial to mesenchymal transition and invasive migration of cancer cells. DT-6 can be used for cancer diseases research[1]. |
| Target | TGF-β |
| Invitro | DT-6 (0.1-50 μM, 0-18 小时) 降低 THP-1, BV2, A549, MCF-7, U87, 和 HepG2 细胞中 TGF-β1 的蛋白表达量[1]。DT-6 (50 μM, 24 小时) 降低条件培养基 (CM) 培养 M2 巨噬细胞中 TGF-β1 的分泌[1]。DT-6 (20 μM,50 μM, 24 小时, 48小时) 通过减少 TGF-β1 的分泌，抑制 M2 巨噬细胞对上皮细胞向间质细胞转化 (EMT) 和癌细胞侵袭性迁移的诱导能力[1]。 0 --> DT-6 相关抗体: |
| Name | DT-6 |
| CAS | 2414315-95-8 |
| Formula | C89H130N20O29S2 |
| Molar Mass | 2008.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Feng Y, et al. Degradation of intracellular TGF-β1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events. Chem Commun (Camb). 2020 Mar 5;56(19):2881-2884. |
DT-6
CAS: 2414315-95-8 F: C89H130N20O29S2 W: 2008.23
DT-6 is an effective TGF-β1 inhibitor. DT-6 inhibits M2 macrophage induced epithelial to mesenchymal transition and inv
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.