| Bioactivity | DSM-421 is an orally active Dihydroorotate dehydrogenase inhibitor. DSM-421 has antiplasmodium activity[1]. |
| In Vivo | DSM-421 (0.1-30 mg/kg, 口服, 连续 4 天) 在恶性疟原虫 SCID 小鼠模型中具有较强的抗疟活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 2011769-21-2 |
| Formula | C14H11F5N6 |
| Molar Mass | 358.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Phillips MA, et al. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis. 2016 Dec 9;2(12):945-957. |