| Bioactivity | DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer[1]. |
| Target | IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation) |
| Invitro | DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1]. Cell Viability Assay[1] Cell Line: |
| Name | DS01080522 |
| CAS | 2832159-84-7 |
| Formula | C23H20Cl2N4O3 |
| Molar Mass | 471.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Toyota A, et al. Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model. Biochem Biophys Res Commun. 2022 Sep 17;621:157-161. |
DS01080522
CAS: 2832159-84-7 F: C23H20Cl2N4O3 W: 471.34
DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kin
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