| Bioactivity | DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1]. |
| Target | IC50: 20 nM (p53-MDM2 interaction) |
| CAS | 1235575-97-9 |
| Formula | C34H38Cl2F2N6O2S |
| Molar Mass | 703.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23(10):2360-7. |
DS-5272
CAS: 1235575-97-9 F: C34H38Cl2F2N6O2S W: 703.67
DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (
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