| Bioactivity | DS-22-inf-021 is a neuraminidase (NA) inhibitor. DS-22-inf-021 has antiviral activity against influenza viruses[1]. |
| Invitro | DS-22-inf-021 抑制 IBV (B/Samara/32/2018 Yamagata 谱系) 和携带 H275Y 突变的耐药 IAV A/Vladivostok/2/2009 (H1N1 pdm09) 的 NA 活性，IC50 值分别为 9.1 μM 和 14.7 µM[1]。DS-22-inf-021 (0.5-50 μM，10 小时) 在感染 IAV 和 IBV 株的 MDCK 细胞中显示出抗病毒活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DS-22-inf-021 相关抗体: |
| In Vivo | DS-22-inf-021 (20-100 mg/kg，腹腔注射，每天两次，持续 5 天，监测 14 天) 提高感染 IAV 和 IBV 的小鼠的存活率[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 945170-74-1 |
| Formula | C20H23N3O2 |
| Molar Mass | 337.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Izmailyan R, et al. Discovery of new antiviral agents through artificial intelligence: In vitro and in vivo results. Antiviral Res. 2024 Feb;222:105818. |