| Bioactivity | DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1]. | ||||||||||||
| In Vivo | DS-1971a exhibits a favorable toxicological profile[1].DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice[1]. Animal Model: | ||||||||||||
| Name | DS-1971a | ||||||||||||
| CAS | 1450595-86-4 | ||||||||||||
| Formula | C20H21ClFN5O3S | ||||||||||||
| Molar Mass | 465.93 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Shinozuka T, et al. Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor [published online ahead of print, 2020 May 26]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00259. |
DS-1971a
CAS: 1450595-86-4 F: C20H21ClFN5O3S W: 465.93
DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV
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