DRP1i27 dihydrochloride_product_DataBase

Bioactivity	DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1].
Invitro	DRP1i27 (0-50 μM) dihydrochloride 直接结合并抑制人 Drp1 的 GTPase 活性[1]。DRP1i27 (0-50 μM) dihydrochloride 能够以 Drp1 依赖性方式增加人和小鼠成纤维细胞中线粒体的细胞网络[1]。DRP1i27 dihydrochloride 在 SPR 分析中的结合亲和力为 286 μM，在 MST 分析中的 KD 值为 190 μM[1]。 0 --> DRP1i27 dihydrochloride 相关抗体:
Name	DRP1i27 dihydrochloride
Formula	C20H28Cl2N6O
Molar Mass	439.38
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531.

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