| Bioactivity | DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14)[1]. |
| Invitro | DR4485 (MZ54 WT cells; 6 µM or 8 µM) hydrochloride induces autophagy as well as cell death that is diminished by KO of ATG5 and ATG7[2]. |
| Name | DR4485 hydrochloride |
| CAS | 402942-53-4 |
| Formula | C26H29Cl3N2O |
| Molar Mass | 491.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13(1):61-64. [2]. Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20. |