| Bioactivity | DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively[1]. |
| Invitro | DPTN 是人、小鼠和大鼠 A3AR 的有效拮抗剂。但与人 A3AR 相比，DPTN 对小鼠和大鼠的作用较弱，选择性降低 (约为 A2BAR 的20倍)。[1]。 DNPT (10 μM) 在转染 HEK293 细胞的细胞膜上的结合亲和力测试表明，其对 hA1、hA2A、hA2B 和 hA3 的 Ki 值分别为 162±49、121±42、230±40 和 1.65±0.57 nM[1]。DPTN 在 A1、A2A、A2B和A3 受体上的 Ki 值分别为 411、830、189 和 9.61 nM (小鼠); 333、1147、163、8.53 nM (大鼠)。 |
| Name | DPTN dihydrochloride |
| CAS | 325767-87-1 |
| Formula | C22H20Cl2N4OS |
| Molar Mass | 459.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhan-Guo Gao, et al. Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonist. Purinergic Signal. 2021 Dec;17(4):737-746. |
DPTN dihydrochloride
CAS: 325767-87-1 F: C22H20Cl2N4OS W: 459.39
DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respect
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