| Bioactivity | DPTIP-prodrug 18 (P18) is a orally active and brain-penetrable prodrug of DPTIP (HY-131002). DPTIP-prodrug 18 is a potent nSMase2 inhibitor. DPTIP-prodrug 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-prodrug 18 can be used for brain injury research[1]. |
| Target | nSMase2 |
| Invitro | DPTIP-prodrug 18 is metabolically stable with >75% intact prodrug remaining after 1 h of incubation at 37 °C[1]. |
| In Vivo | DPTIP-prodrug 18 exhibits an excellent PK profile[1]. DPTIP-prodrug 18 shows significant inhibition of nSMase2 activity and IL-1β-induced EV release in mice[1]. Animal Model: |
| Name | DPTIP-prodrug 18 |
| CAS | 2881068-33-1 |
| Formula | C36H44N4O4S |
| Molar Mass | 628.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pal A, et al. Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP. J Med Chem. 2022 Aug 5. |
DPTIP-prodrug 18
CAS: 2881068-33-1 F: C36H44N4O4S W: 628.82
DPTIP-prodrug 18 (P18) is a orally active and brain-penetrable prodrug of DPTIP (HY-131002). DPTIP-prodrug 18 is a poten
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This product is for research use only, not for human use. We do not sell to patients.