| Bioactivity | DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)[1]. |
| Invitro | DPP-4-IN-8 (compound 27) 对正常细胞无毒性，对癌细胞有微弱毒性[1]。 0 --> DPP-4-IN-8 相关抗体: |
| Name | DPP-4-IN-8 |
| Formula | C16H12ClNO6 |
| Molar Mass | 349.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li CQ, et al. Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects. J Nat Prod. 2023 Jul 28;86(7):1824-1831. |