| Bioactivity | DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC50 of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC50 of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with 68Ga, and used for research about cancer[1]. |
| Target | IC50: 0.9 nM (FAP); 5.4 μM (PREP) |
| Formula | C45H56F5N11O14 |
| Molar Mass | 1069.98 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Moon ES, et al., Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. |
DOTA.SA.FAPi TFA
CAS: F: C45H56F5N11O14 W: 1069.98
DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA
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