DOTA Conjugated JM#21 derivative 7_product_DataBase

Bioactivity	DOTA Conjugated JM#21 derivative 7 is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body[1].
CAS	3033865-40-3
Sequence	{d-Ile}-LRWSRK-Lys(DOTA)-NH2
Shortening	{d-Ile}-Leu-Arg-Trp-Ser-Arg-Lys-Lys(DOTA)-NH2
Formula	C66H114N22O16
Molar Mass	1471.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Juliano R L, et al. Liposomes as a drug delivery system for antisense oligonucleotides[J]. Antisense research and development, 1992, 2(2): 165-176.

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