| Bioactivity | DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia[1][2]. |
| CAS | 1088991-95-0 |
| Formula | C23H22F2N4O2 |
| Molar Mass | 424.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43(3):zsz241. [2]. Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19. |
DORA-22
CAS: 1088991-95-0 F: C23H22F2N4O2 W: 424.44
DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairmen
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