| Bioactivity | DOPE-mPEG (MW 2000) is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG (MW 2000) significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner[1][2][3]. |
| Name | DOPE-mPEG (MW 2000) |
| Molar Mass | 2000(Average) |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shin J, et al. Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Mol Pharm. 2012 Nov 5;9(11):3266-76. [2]. Su WC, et al. Pulsatile Gating of Giant Vesicles Containing Macromolecular Crowding Agents Induced by Colligative Nonideality. J Am Chem Soc. 2018 Jan 17;140(2):691-699. [3]. Xu H, et al. Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug. Pharm Res. 2015 Jul;32(7):2428-38. |