| Bioactivity | DNMT3A-IN-3 is an allosteric DNA methyltransferase 3A (DNMT3A) inhibitor. DNMT3A-IN-3 binds and disrupt protein-protein interactions (PPIs) at the DNMT3A tetramer interface[1]. |
| Invitro | DNMT3A-IN-3 (compound 1) 会破坏 DNMT3A_WT 同四聚体或异四聚体，但不会与组蛋白 H3 尾相互作用[1]。DNMT3A-IN-3 (compound 1) 与 AdoMet 结合的 Ki 值为 3.70-7.06 μM[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DNMT3A-IN-3 相关抗体: |
| Formula | C30H38N6O4 |
| Molar Mass | 546.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jonathan E SandovalA, et al. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022 Aug 11;65(15):10554-10566. [2]. Sunzeyu Huang, et al. A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A. Bioorg Med Chem Lett. 2021 May 15:40:127908. |