| Bioactivity | DNMT3A-IN-2 (compound 1a) is a hydrophthalazinone-based inhibitor of DNA methyltransferase 3A (DNMT3A) (IC50: 14 μM) against S-adenosylmethionine (SAM) has a Ki of 9.16-18.85 μM.[14][1]. |
| In Vivo | DNMT3A-IN-2 显著降低急性髓系白血病小鼠模型中的 DNMT3A 活性，并展示了较低的细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C33H40N6O4 |
| Molar Mass | 584.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hernandez I, et al. Structural Investigations of Phthalazinone Derivatives as Allosteric Inhibitors of Human DNA Methyltransferase 3A[J]. ACS Medicinal Chemistry Letters, 2024. |