| Bioactivity | DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety[1]. |
| Target | IC50: 0.4 μM (T. cruzi) |
| In Vivo | DNDI-8219 (50 or 100 mg/kg; PO; once daily for five days) completely cures chronic infection, as well as markedly reduces parasite burdens in mice[1]. Animal Model: |
| Name | DNDI-8219 |
| CAS | 2222660-40-2 |
| Formula | C13H10F3N3O5 |
| Molar Mass | 345.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thompson AM, et al. Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. Eur J Med Chem. 2020;207:112849. |
DNDI-8219
CAS: 2222660-40-2 F: C13H10F3N3O5 W: 345.23
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity again
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