DNA topoisomerase II inhibitor 1_product_DataBase

Bioactivity	DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase[1].
Invitro	DNA topoisomerase II inhibitor 1 (compound 8ed) (0-10 µM; 48 h) shows cytotoxic activity with IC50s of 10.10, >10, 0.59, 4.20, >10, >10, 8.41 µM for HT-29, MDA-MB-231, MG-63, U87MG, PC3, HeLa, Vero cells, respectively[1].DNA topoisomerase II inhibitor 1 (0.5, 2 µM; 24 h) induces apoptosis and cell cycle arrest at sub G1 phase[1].DNA topoisomerase II inhibitor 1 (0.5, 2 µM) increases the generation of reactive oxygen species (ROS)[1].
Name	DNA topoisomerase II inhibitor 1
CAS	2459950-15-1
Formula	C28H24N4O3S
Molar Mass	496.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lakshmi Manasa K, et al. Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability. Bioorg Chem. 2020 Aug;101:103983.

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