| Bioactivity | DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC50=6.29 μg/mL[1]. |
| Target | IC50: 6.29 μg/mL (DNA gyrase in S. aureus) |
| Name | DNA Gyrase-IN-9 |
| Formula | C26H18ClN3O2 |
| Molar Mass | 439.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Almaghrabi M, et al. Introducing of novel class of pyrano [2, 3-c] pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation[J]. Journal of Biomolecular Structure and Dynamics, 2023: 1-18.. . . |