| Bioactivity | DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains[1]. |
| Target | IC50: 0.10 μM (DNA gyrase) |
| Invitro | DNA Gyrase-IN-5 (Compound 8I-w) shows antibacterial activities with IC50 values of 4.7, 7.0, 17.0, 13.5, 1.0, 25.3 and 47.8 μM against E. coli, E. coli E564, E. coli E68, E. coli E48, E. coli E109, Salmonella and S. aureus, respectively[1]. |
| Name | DNA Gyrase-IN-5 |
| CAS | 2417016-23-8 |
| Formula | C25H15BrClN5 |
| Molar Mass | 500.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu H, et al. Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase. Bioorg Chem. 2020 Jun;99:103807. |
DNA Gyrase-IN-5
CAS: 2417016-23-8 F: C25H15BrClN5 W: 500.78
DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibac
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