| Bioactivity | DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities[1]. |
| Invitro | DN401（5-20 µM；24 小时）具有优异的癌症特异性细胞毒性，但在正常细胞中的细胞毒性作用降低[1]。DN401（20 µM；6 小时）抑制 HeLa 细胞中 Chk1 和 Akt 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DN401 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | DN401（30 mg/kg；腹腔注射；每天一次；持续 14 天）可减少肿瘤生长并增加肿瘤组织中的细胞凋亡，并且不会导致体重减轻或组织学异常[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2135749-60-7 |
| Formula | C13H9BrClN5O2 |
| Molar Mass | 382.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hye-Kyung Park, et al. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J Med Chem. 2017 Sep 14;60(17):7569-7578. |