| Bioactivity | DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity[1]. |
| Invitro | DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively[1].DMUP (5 µM, 24 h) arrests the cell cycle in S phase in A549 cells[1].DMUP (5 µM, 48 h) induces apoptosis in A549 cells[1].DMUP (5 µM, 24 h) decreases the expression of CD47 and SIRPα protein[1].DMUP (5 µM, 4 h) increases the macrophage phagocytosis in A549-GFP cells[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | DMUP |
| CAS | 2364350-07-0 |
| Formula | C24H24Cl2N2O10Pt |
| Molar Mass | 766.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
DMUP
CAS: 2364350-07-0 F: C24H24Cl2N2O10Pt W: 766.44
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 ce
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