| Bioactivity | DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2]. | |||||||||
| Name | DM4-SMe | |||||||||
| CAS | 796073-68-2 | |||||||||
| Formula | C39H56ClN3O10S2 | |||||||||
| Molar Mass | 826.46 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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DM4-SMe
CAS: 796073-68-2 F: C39H56ClN3O10S2 W: 826.46
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of
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