| Bioactivity | DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF)[1][2]. |
| CAS | 865488-53-5 |
| Formula | C13H15NO5 |
| Molar Mass | 265.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20(18):1812-1827. [2]. Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14(43):12098-12120. |