| Bioactivity | DL-threo-PPMP is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP inhibits the activity of sphingosine synthetase by mimicking the substrate sphingosine. This inhibition leads to a rapid decrease in the activity of sensitive sphingosine synthetase, selectively destroying the interconnected tubular network of TVMs in the host cell cytoplasm, and this inhibition also blocks the proliferation of Plasmodium falciparum. DL-threo-PPMP can be used for the study of Plasmodium biology and the search for new antimalarial strategies[1]. |
| CAS | 149022-18-4 |
| Formula | C29H50N2O3 |
| Molar Mass | 474.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lauer S A, et al. Sphingolipid synthesis as a target for chemotherapy against malaria parasites[J]. Proceedings of the National Academy of Sciences, 1995, 92(20): 9181-9185. |
DL-threo-PPMP
CAS: 149022-18-4 F: C29H50N2O3 W: 474.72
DL-threo-PPMP is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP inhibits the activity of
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