| Bioactivity | DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase(ERK) signalling cassette inhibitor and is effective against both growth factor- and G-protein-dependent activation of ERK. DL-threo-Dihydrosphingosine inhibits smooth muscle cell proliferation and can be used for study of asthma[1][2]. |
| CAS | 2304-75-8 |
| Formula | C18H39NO2 |
| Molar Mass | 301.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tolan D, et al. The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br J Pharmacol. 1996;119(2):185-186. [2]. Yoshida K, et al. ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice. J Allergy Clin Immunol. 2023;151(4):1067-1080.e9. |
DL-threo-Dihydrosphingosine
CAS: 2304-75-8 F: C18H39NO2 W: 301.51
DL-threo-Dihydrosphingosine is a extracellular signal-regulated kinase(ERK) signalling cassette inhibitor and is effecti
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