| Bioactivity | DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1. |
| Name | DL-threo-2-methylisocitrate sodium |
| Formula | C14H14Na6O14 |
| Molar Mass | 544.19 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Gould TA, et al. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7. |
DL-threo-2-methylisocitrate sodium
CAS: F: C14H14Na6O14 W: 544.19
DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant
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