| Bioactivity | DL-Penicillamine [(±)-Penicillamine] is a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A). DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response[1][2][3]. | ||||||||||||
| In Vivo | DL-Penicillamine (25 mg/kg; i.p.; twice daily, for 5 days) has antidotal effects in thallotoxicosis rats when co-treated with Prussian blue (HY-106594A)[2]. Animal Model: | ||||||||||||
| Name | DL-Penicillamine | ||||||||||||
| CAS | 52-66-4 | ||||||||||||
| Formula | C5H11NO2S | ||||||||||||
| Molar Mass | 149.21 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. TU J, BLACKWELL RQ, LEE PF. DL-penicillamine as a cause of optic axial neuritis. JAMA. 1963 Jul 13;185:83-6. [2]. Montes S, et al. Additive effect of DL-penicillamine plus Prussian blue for the antidotal treatment of thallotoxicosis in rats. Environ Toxicol Pharmacol. 2011 Nov;32(3):349-55. [3]. Huebner Kf, Gengozian N. Depression Of The Primary Immune Response By Dl-Penicillamine. Proc Soc Exp Biol Med. 1965 Feb;118:561-5. |
DL-Penicillamine
CAS: 52-66-4 F: C5H11NO2S W: 149.21
DL-Penicillamineis a copper chelating agent. DL-Penicillamine has antidotal effects in thallotoxicosis rats when co-trea
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