| Bioactivity | DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect[1][2][3]. |
| Invitro | DL-AP3 (10 µM，6 小时) 减轻原代神经元中氧-葡萄糖剥夺 (OGD) 引起的损伤 (细胞活力)[1]。DL-AP3 (10 µM，6 小时) 恢复原代神经元中 OGD 诱导的 p-Akt1 水平降低和细胞色素 C 增加[1]。DL-AP3 (1-100 µM) 抑制大鼠脑磷酸丝氨酸磷酸酶的活性，IC50 为 187 µM，Ki 为 77 µM[2]。DL-AP3 (10 μM, 10min) 联合 SKF81297 (5 μM) 在 Fmr1 KO 小鼠的切片中诱导显著的的长时程增强 (LTP)[3]。 Cell Viability Assay[1] Cell Line: |
| Name | DL-AP3 |
| CAS | 5652-28-8 |
| Formula | C3H8NO5P |
| Molar Mass | 169.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |