| Bioactivity | DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells[1]. |
| Invitro | DIZ-3 (0-40 μM; 24 小时) 抑制 ALT 癌细胞系的增殖[1]。 DIZ-3 (0.6-2.5 μM; 24小时) 诱导 U2OS 细胞周期停滞和细胞凋亡[1]。 DIZ-3 (0.12, 0.25, 0.5 μM; 7 天) 导致 U2OS 细胞集落形成[1]。 DIZ-3 (0.12, 0.25, 0.5 μM; 24小时) 显着抑制 U2OS 细胞的迁移[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | DIZ-3 |
| CAS | 2675490-72-7 |
| Formula | C46H44F2N8 |
| Molar Mass | 746.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ming-Hao Hu, et al. Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere. Eur J Med Chem. 2020 Jan 15;186:111891. |