| Bioactivity | DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1[1]. |
| Target | Selenium, iNOS, TNF-α |
| Invitro | DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells[1].DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors[1].DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | DHU-Se1 |
| Formula | C23H23N3OSSe |
| Molar Mass | 468.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peng H, et al. HOCl-Activated Reactive Organic Selenium Delivery Platform for Alleviation of Inflammation. Bioconjug Chem. 2022 Aug 26. |