| Bioactivity | DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1]. |
| Target | IC50: 4 μM (PfDHODH), 0.18 μM (HsDHODH). |
| Name | DHODH-IN-4 |
| CAS | 1148125-93-2 |
| Formula | C17H12Cl2N2O2 |
| Molar Mass | 347.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93. |
DHODH-IN-4
CAS: 1148125-93-2 F: C17H12Cl2N2O2 W: 347.20
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50
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