| Bioactivity | DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 nM for human DHODH. DHODH-IN-25 can be used for the study of acute myeloid leukemia (AML)[1]. |
| Target | IC50: 5.4 nM (hDHODH). |
| CAS | 2619531-95-0 |
| Formula | C22H19ClF5N3O5 |
| Molar Mass | 535.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. DeRatt, Lindsey G., et al. "Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors." ACS Medicinal Chemistry Letters (2024). |
DHODH-IN-25
CAS: 2619531-95-0 F: C22H19ClF5N3O5 W: 535.85
DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 value of 5.4 n
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