| Bioactivity | DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway[1]. |
| Target | IC50: 25 nM (DHODH) |
| Invitro | DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM)[1]. DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells[1]. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules[1]. Cell Proliferation Assay[1] Cell Line: |
| In Vivo | DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1]. |
| Name | DHODH-IN-1 |
| CAS | 1800296-63-2 |
| Formula | C21H20F3N3O2 |
| Molar Mass | 403.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98. |
DHODH-IN-1
CAS: 1800296-63-2 F: C21H20F3N3O2 W: 403.40
DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 25 nM. DHODH-IN-1 i
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