| Bioactivity | DHHC3 degrader 1 is a CRBN-based cp-PCC with aDC50 value for DHHC3 degradation of 102 nM. DHHC3 degrader 1 is the target protein ligand of (HY-169232) PROTAC. DHHC3 degrader 1 has antitumor activity[1]. |
| Sequence | {Rhodmine B}-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Gly-Ile-Gln-Asp-Thr-Asn-Ser-Lys-Lys-Gln-Ser-Asp-Thr-His-Leu-Glu-Glu-Thr-Lys-NH2 |
| Shortening | {Rhodmine B}-YGRKKRRQRRRCGIQDTNSKKQSDTHLEETK-NH2 |
| Formula | C183H298ClN63O51S |
| Molar Mass | 4264.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shi YY, et al. Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates. Cell Death Dis. 2024 Sep 30;15(9):701. |
DHHC3 degrader 1
CAS: F: C183H298ClN63O51S W: 4264.23
DHHC3 degrader 1 is a CRBN-based cp-PCC with aDC50 value for DHHC3 degradation of 102 nM. DHHC3 degrader 1 is the target
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