| Bioactivity | DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection[1]. |
| Name | DHFR-IN-8 |
| Formula | C18H14N6S |
| Molar Mass | 346.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu Z, et al. Exploration and Biological Evaluation of 1, 3-Diamino-7 H-pyrrol [3, 2-f] quinazoline Derivatives as Dihydrofolate Reductase Inhibitors[J]. Journal of Medicinal Chemistry, 2023.. . . |